Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| hematopoietic stem cell transplantation |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Variant |
Stem cell transplantation
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| Definition |
The process of infusing healthy stem cells into persons who have undergone high-dose chemotherapy for one of many forms of leukemia, immunodeficiency, lymphoma, anemias, thalassemias or metabolic disorders. There are three types of stem cell transplants: autologous, allogeneic and syngeneic. Healthy stem cells are collected from bone marrow, peripheral blood, and umbilical cord blood. Once the healthy stem cells are infused into the patient´s blood stream, the cells move from the blood vessels to the bone marrow spaces, where they begin making new blood cells.The primary source of hematopoietic stem and progenitor cells for use in autologous and allogeneic transplantation has been bone marrow. More recently, use of peripheral blood as a source of these cells has increased. This product is referred to variously as peripheral blood stem cells (PBSC), peripheral blood progenitor cells (PBPC), or stem cells. Although each cell source used for hematopoietic transplantation contains stem cells, when the term stem cells is used without a qualifier, it usually refers to PBSC.
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| Definition source |
National Marrow Donor Program (NMDP). Glossary.
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| Context |
Preliminary results of allogeneic stem cell transplantation in many single centers and a small randomized trial indicate more rapid hematopoietic recovery with this method than with allogeneic bone marrow transplantation.
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| Context source |
Richard E., et al. (2000). ‘Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogeneic transplantation’. Blood 95(12): 3702-3709. (RISCEN70)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Specific concept |
Allogeneic bone marrow transplantation, syngeneic bone marrow transplantation, autologous bone marrow transplantation, in utero stem cell transplantation
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| Related concept |
Hematopoietic stem cell, marrow cavity, bone marrow space, engraftment, rejection, Graft-Versus-Host Disease, conditioning regimen, immunosuppression, total body irradiation
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| it |
Trapianto di cellule staminali emopoietiche
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| Reliability code |
3
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