| English |
| autologous bone marrow transplantation |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
|
| Grammatical label |
Countable
|
| Variant |
Autologous transplantation, autologous marrow transplantation, autologous BMT
|
| Definition |
In autologous transplantation, patients receive their own marrow or peripheral stem cells. Because the patient is the donor, HLA matching is not necessary; moreover, there is virtually no risk of GVHD. For autologous transplantation to be successful, the patient´s marrow must be relatively free of disease when it is harvested. In some patients, autologous transplantation is feasible because the cancer does not involve the bone marrow. (A sample of the bone marrow, removed through bone marrow aspiration, is checked for the presence of cancer cells.) In other patients, such as leukemia and lymphoma patients, initial treatment to induce remission (the disappearance of the signs of cancer) is necessary before bone marrow harvesting. Depending on their disease and other factors, patients may then either proceed immediately with the high-dose treatment and transplantation procedure or store their marrow and proceed with high-dose treatment and transplantation only if their disease returns.
|
| Definition source |
Universität Göttingen. Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation. (INTEEN04)
|
| Context |
The incidence of leukemic recurrence in patients given an autologous marrow transplantation during relapse (marrow harvested during remission) is very high.
|
| Context source |
Atkinson, K. (1984). ‘Clinical bone marrow transplantation: current status’. Transplantation Proceedings 16(4):1009-15. (RISCEN114)
|
| Subject field |
Haemopoiesis
|
| Sub-field (level 1) |
Thalassemias
|
| Sub-field (level 2) |
Therapies
|
| Generic concept |
Hematopoietic stem cell transplantation, in utero stem cell transplantation
|
| Coordinate concept |
Allogeneic bone marrow transplantation, syngeneic bone marrow transplantation
|
| Related concept |
Hematopoietic stem cell, marrow cavity, bone marrow space, engraftment, Graft-Versus-Host Disease, relapse, conditioning regimen, immunosuppression, total body irradiation
|
| it |
Trapianto di midollo osseo autologo
|
| Reliability code |
3
|
