| English |
| hematopoietic stem cell |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
|
| Grammatical label |
Countable
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| Variant |
Stem cell
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| Definition |
All blood cells develop from very immature cells called hematopoietic stem cells. Most stem cells are found in the bone marrow, although some, called peripheral blood stem cells, circulate in blood vessels throughout the body. Hematopoietic stem cells can divide to form more stem cells, or they can go through a series of cell divisions by which they become fully mature blood cells. Most blood cells mature in the bone marrow. However, some white blood cells (also called lymphocytes) complete their maturation in the thymus, spleen, or lymph nodes.
|
| Definition source |
Universität Göttingen. Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation. (INTEEN04)
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| Context |
Hematopoietic stem cells are a self-renewing tissue, which can be removed for the ex vivo insertion of the normal gene. The hematopoietic stem cells can then be returned to the patient. Theoretically, the autologous transplantation of a patient´s stem cells following the insertion of the normal gene should result in the same clinical benefits as the transplantation of genetically normal allogeneic bone marrow without the associated immunologic problems.
|
| Context source |
Ohene-Frempong, K., et al. (1987). ‘Thalassemia syndromes. Recent advances’. Hematology Oncology Clinics of North America 1(3):503-19. (RISCEN177)
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| Figure source |
http://www.ece.umn.edu/users/tannenba/yezzi_stem.html
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
|
| Comprehensive concept |
Bone marrow
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| Specific concept |
CD34+ cell, committed erythroid progenitor cell, committed precursor cell
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| Related concept |
Hematopoietic stem cell transplantation, in utero stem cell transplantation
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| it |
Cellula staminale emopoietica
|
| Reliability code |
3
|
