A small white blood cell (leukocyte) that plays a large role in defending the body against disease. Lymphocytes are responsible for immune responses. There are two main types of lymphocytes: B cells and T cells. The B cells make antibodies that attack bacteria and toxins while the T cells attack body cells themselves when they have been taken over by viruses or have become cancerous. Lymphocytes secrete products (lymphokines) that modulate the functional activities of many other types of cells and are often present at sites of chronic inflammation.
The first patient treated by in utero FLCT 10 years ago had bare lymphocyte syndrome (BLS), a genetically transmitted form of combined immunodeficiency due to the lack of HLA antigens. At birth, no lymphopenia is apparent but the lymphocytes are not functional: the patients do not mount an efficient cellular response to antigens from microorganisms and they are severely hypogammaglobulinemic.
Touraine, JL. (1999). ‘Induction of transplantation tolerance in humans using stem cell transplants prenatally or postnatally’. Transplantation Proceedings 31(7):2735-7. (RISCEN107)