To rescue the patient, reserved or donor marrow or peripheral blood is delivered intravenously to rescue the patient. The process of infusion is much like a blood transfusion. The marrow cells find their way through the bloodstream to the center of the long bones.
The presence of RHC in a patient after transplantation represents a risk factor for graft failure. None of the patients showing full donor engraftmentrejected the transplant, but 29% of patients with MC rejected the graft within 2 years from the marrow infusion.
Giardini, C. & Lucarelli, G. (1999). Bone Marrow Transplantation for beta-thalassemia’. Hematology Oncology Clinics of North America 13(5):1059-64. (RISCEN173)