Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| allogeneic bone marrow transplantation |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Variant |
Bone marrow transplantation, marrow transplantation, marrow transplant, allogeneic transplantation, BMT, allogeneic BMT
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| Definition |
Allogeneic bone marrow transplantation, in which bone marrow comes from a person other than the patient or an identical sibling, is the most common case of marrow transplant. Usually the patient´s sibling or parent serves as the donor, but unrelated donors are sometimes used. (In rare cases, a child may donate marrow for a parent.).The success of allogeneic transplantation depends largely on how closely the HLA antigens of the donor´s marrow match those of the recipient´s marrow, which is determined by special blood tests. (The matching of bone marrow is a much more complicated process than is the matching of blood types. Scientists look at six HLA antigens, and most institutions require a match on at least five of these proteins.) The higher the number of matches, the greater the chance that a patient´s body will accept the graft. A good HLA match also reduces the chance that the transplanted bone marrow will react against the patient´s body. This reaction, called graft-versus-host disease (GVHD), is a potentially serious complication of BMT.
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| Definition source |
Universität Göttingen. Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation. (INTEEN04)
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| Context |
In the absence of specific gene therapy, allogeneic bone marrow transplantation is the only rational therapeutic modality for eradication of beta-thalassemia major.
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| Context source |
Ghavamzadeh, A., et al. (1998). ‘Prognostic factors in bone marrow transplantation for beta thalassemia major: experiences from Iran’. Bone Marrow Transplantation 22(12):1267-1169. (RISCEN127)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Generic concept |
Hematopoietic stem cell transplantation, in utero stem cell transplantation
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| Coordinate concept |
Autologous bone marrow transplantation, syngeneic bone marrow transplantation
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| Related concept |
Hematopoietic stem cell, marrow cavity, bone marrow space, engraftment, rejection, Graft-Versus-Host Disease, relapse, conditioning regimen, immunosuppression, total body irradiation
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| it |
Trapianto di midollo osseo allogenico
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| Reliability code |
3
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