|
|
|
Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| eradication |
  |
|
| Attestation |
3
|
| Part of speech |
Noun
|
| Grammatical label |
Countable
|
| Variant |
In-vivo eradication
|
| Definition |
Removal of the host hematopoielic system to ensure complete engraftment after bone marrow or stem cell transplantation.
|
| Definition source |
Kapelushnik, J., et al. (1995). ‘Analysis of beta-globin mutations shows stable mixed chimerism in patients with thalassemia after bone marrow transplantation’. Blood 86(8):3241-6. (RISCEN79)
|
| Context |
There are two fundamental treatments in the pre-transplant preparation: eradication of the hemopoietic system by administration of a total dose of 14-16 mg/kg of busulfan; suppression of the immune system by administration of a total dose of 200mg/kg of cyclophosphamide.
|
| Context source |
Lucarelli, G., et al. (2001). ‘The cure of thalassemia with bone marrow transplantation’. Bone Marrow Transplantation 28(S1):511-513. (RISCEN116)
|
| Subject field |
Haemopoiesis
|
| Sub-field (level 1) |
Thalassemias
|
| Sub-field (level 2) |
Therapies
|
| Specific concept |
Myeloablation
|
| Related concept |
Allogeneic bone marrow transplantation, syngeneic bone marrow transplantation, hematopoietic stem cell transplantation, marrow cavity, bone marrow space, total body irradiation, conditioning regimen, mixed chimerism
|
| it |
Eradicazione
|
| Reliability code |
3
|
|
