Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| follow-up (en.) |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Definition |
The patient´s and parents´ agreement to long-term follow-up should be obtained prior to transplantation (otherwise “cured” patients may feel they no longer need to see a doctor). Transplanted patients should be seen at least monthly initially, and at least yearly/or life. Follow-up should include monitoring of: • Status of the graft • Status of iron overload. Residual iron should be removed, using either phlebotomy or Desferal. • Status of any complications already present prior to transplantation • Possible transplant-related problems such as secondary malignancies • Progress of growth and sexual development Follow-up is also essential to compare long-term survival and disease-free survival in transplanted patients and conventionally-treated patients.
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| Definition source |
Cao, A., et al. (1997). Management Protocol for the treatment of Thalassemia patients. Nicosia: Thalassemia International Federation. (LISCEN01)
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| Context |
Moreover, prolonged follow-up with monitoring by sequential liver biopsies has shown that patients with severe pretransplant liver damage and high iron stores may have progression of liver fibrosis after BMT.
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| Context source |
Angelucci, E., et al. (1997). ‘Phlebotomy to reduce iron overload in patients cured of thalassemia by bone marrow transplantation. Italian Cooperative Group for Phlebotomy Treatment of Transplanted Thalassemia Patients’. Blood 90(3):994-8. (RISCEN75)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Related concept |
Allogeneic bone marrow transplantation, syngeneic bone marrow transplantation, hematopoietic stem cell transplantation, Graft-Versus-Host Disease, rejection, immunosuppression, mixed chimerism, engraftment
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| it |
Follow-up (It.)
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| Reliability code |
3
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