Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| desferrioxamine |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
|
| Grammatical label |
Countable
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| Variant |
DF, DFO
|
| Definition |
The iron chelator desferrioxamine (Desferal) is used to remove excess iron that accumulates with chronic blood transfusions. Desferrioxamine can be used to treat iron overload since the drug binds iron with a large preference over other metal ions such as calcium (Kd=10-31 M for iron, Kd=10-9 M for calcium). A clinically highly effective iron chelator such as desferrioxamine has the drawback of very poor absorption from the gastrointestinal tract. Consequently the drug must be given parenterally, as a continuous subcutaneous infusion, or as a continuous intravenous infusion. The expensive medical paraphernalia required for desferrioxamine administration makes the treatment expensive, and curbs its availability in areas of the world where medical resources are limited. Even when the resources exist to support iron chelation with desferrioxamine, the intrusiveness of pumps and other paraphernalia often impedes patient compliance.
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| Definition source |
Joint Center for Sickle Cell and Thalassemic Disorders. Thalassemia Overview. (INTEEN05)
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| Context |
Transfusions and regular iron chelation with desferrioxamine remain the cornerstones of the conventional treatment for severe b-thalassemia, which has dramatically improved survival and quality of life in these patients.
|
| Context source |
Lucarelli, G., et al. (1995). ‘Bone marrow transplantation in thalassemia’. Seminars in Hematology 32(4):297-303. (RISCEN178)
|
| Synonym |
Desferal, deferoxamine
|
| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
|
| Generic concept |
Iron-chelating agent
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| Coordinate concept |
Deferiprone, HES-DFO
|
| Related concept |
Serum ferritin, iron-chelation therapy, chelation
|
| it |
Desferrioxamina
|
| Reliability code |
3
|
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