Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| iron-chelating agent |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Variant |
Iron-chelating drug
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| Definition |
Iron chelating agents are used to remove excess iron from the body. This may be necessary in certain patients with anemia who must receive blood transfusions. It is also used to treat acute iron poisoning, especially in children. Deferoxamine is the intravenously administered chelation agent currently approved for use in the United States. It is a very well known chelating agent, that combines with iron in the bloodstream. The combination of iron and deferoxamine is then removed from the body by the kidneys. By removing the excess iron, the medicine lessens damage to various organs and tissues of the body. This medicine may be used for other conditions as determined by your doctor. Deferiprone is an oral chelation agent, recently approved for use in Europe. While the results of studies on this oral agent are encouraging, complications of liver fibrosis may develop Deferiprone currently is not approved for use in the United States.
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| Definition source |
Takeshita, K. (2002). Thalassemia, Beta. E-Medicine. (INTEEN10)
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| Context |
The experience with DF is beginning to confirm that removal of iron in thalassaemia is likely to be of clinical benefit. This should provide a further stimulus to the development of a cheaper, orally active iron-chelating agent.
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| Context source |
Pippard, MJ. (1987). ‘Iron overload and iron chelation therapy in thalassaemia and sickle cell haemoglobinopathies’. Acta Haematology 78(2-3):206-11. Review. (RISCEN160)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Specific concept |
Desferrioxamine, deferiprone, HES-DFO
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| Related concept |
Iron-chelation therapy, chelation, hemochromatosis, hemosiderosis, hepatosplenomegaly, splenectomy
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| it |
Farmaco ferrochelante
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| Reliability code |
3
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