| English |
| hla-identical donor |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
|
| Grammatical label |
Countable
|
| Variant |
Identical donor
|
| Definition |
Marrow or stem cell donor that is genotypically identical to the the thalassemic patient as far as the HLA system is concerned. Bone marrow transplantation (BMT) from an HLA-identical donor is a rational therapeutic modality for the cure of b-thalassemia major as well as for other hemoglobinopathies. In the great majority of transplanted thalassemic patients, a full donor engraftment is observed and the donor´s type pattern of b globin chain synthesis is established. In some cases, there is the presence of mixed chimerism after BMT. This normally resolves into complete engraftment or leads to graft loss.
|
| Definition source |
Battaglia, M., et al. (1999). ‘Coexistence of two functioning T-cell repertoires in healthy ex-thalassemics bearing a persistent mixed chimerism years after bone marrow transplantation’. Blood 94(10):3432-8. (RISCEN72)
|
| Context |
This 32-year-old male with Philadelphia chromosome-positive acute lymphoblastic leukemia received a bone marrow transplant (BMT) from an HLA-identical donor. We analyzed the bone marrow with the reverse transcriptase-polymerase chain reaction to screen for the minor bcr/abl transcript, which indicates the presence of minimal residual disease (MRD).
|
| Context source |
Kanamori, H., et al. (1997). ‘Eradication of minimal residual disease during graft-versus-host reaction induced by abrupt discontinuation of immunosuppression following bone marrow transplantation in a patient with Ph1-ALL’. Transplant International 10(4):328-30. (RISCEN15)
|
| Synonym |
Identical sibling
|
| Subject field |
Haemopoiesis
|
| Sub-field (level 1) |
Thalassemias
|
| Sub-field (level 2) |
Therapies
|
| Generic concept |
Bone marrow donor, hematopoietic stem cell donor, related donor, HLA-compatible donor
|
| Related concept |
Allogeneic bone marrow transplantation, HLA typing, HLA, hematopoietic stem cell transplantation
|
| it |
Donatore HLA-identico
|
| Reliability code |
3
|
