Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| depletion |
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| Attestation |
3
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| Part of speech |
Noun
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| Grammatical label |
Countable
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| Definition |
A technique for preventing GVHD is depletion, in particular T-cell depletion, which involves eliminating T lymphocytes in the donated marrow before it is given to the patient. The T-cells are removed or destroyed by means of monoclonal antibodies or other processes. Although T-cell depletion appears to reduce the chance that a patient will develop severe GVHD, this technique has other associated risks: Graft failure may be more likely when T-cell depleted marrow is used, and leukemia patients may be more likely to have a relapse.
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| Definition source |
Universität Göttingen. Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation. (INTEEN04)
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| Context |
The helper/suppressor ratio was decreased in patients with evidence of hypersplenism. Patients who had suffered from pneumonia or hepatitis manifested lower mean T cell count depletion of helper cells and decreased helper/suppressor ratio.
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| Context source |
Khalifa, AS., et al. (1998). ‘T cell functions in infants and children with beta-thalassemia’. Acta Haematologica 79(3):153-6. (RISCEN159)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Related concept |
Eradication, conditioning regimen, iron-chelating agent, allogeneic bone marrow transplantation, autologous bone marrow transplantation, hematopoietic stem cell transplantation
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| it |
Deplezione
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| Reliability code |
3
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