Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| identical sibling |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Variant |
Identical twin
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| Definition |
In syngeneic transplantation, bone marrow is taken from an identical sibling. Different people usually have different sets of proteins, called human leukocyte-associated (HLA) antigens, on the surface of their cells that allow white blood cells to distinguish the body´s own cells from those of another person. However, because identical twins have the same genes, they also have the same set of HLA antigens (they are a perfect HLA match). As a result, the patient´s body usually accepts the graft (transplant). Given that identical twins represent only 0.3 percent of all births (1 birth out of every 270), syngeneic transplantation is rare.
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| Definition source |
Universität Göttingen. Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation. (INTEEN04)
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| Context |
As in patients given HLA-identical sibling allografts for end-stage acute leukemia, a small number of patients receiving monozygotic identical twin marrow grafts after che-moradiation are cured.
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| Context source |
Atkinson, K. (1984). ‘Clinical bone marrow transplantation: current status’. Transplantation Proceedings 16(4):1009-15. (RISCEN114)
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| Synonym |
HLA-identical donor
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Generic concept |
Bone marrow donor, HLA typing, HLA, hematopoietic stem cell transplantation
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| Related concept |
Allogeneic bone marrow transplantation, HLA typing, HLA, hematopoietic stem cell transplantation
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| it |
Gemello identico
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| Reliability code |
3
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