Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| aplastic anemia |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
|
| Grammatical label |
Countable
|
| Definition |
Aplastic anemia is a deficiency of certain types of blood cells caused by poor bone marrow function. It is a disease of diverse etiologies characterized by pancytopenia associated with a hypoplastic marrow. Possible pathophysiological mechanisms of aplastic anemia include defective hematopoietic stem cells, a deficient microenvironment of the marrow, impairment of cellular interactions necessary to sustain hematopoiesis, and immune suppression of marrow function. Replacement of the diseased marrow by a graft from a healthy allogeneic donor first requires immunosuppression of the patient so that the genetically disparate graft is accepted.
|
| Definition source |
Storb, R., et al. (1991). ‘Marrow transplantation for severe aplastic anemia an thalassemia major’. Seminars in Hematology 28(3):235-9. Review. (RISCEN180)
|
| Context |
Bone marrow transplantation has been increasingly used to cure aplastic anemia, leukemias, lymphomas, multiple myeloma, thalassemias, and immune deficiency disorders as well as solid tumors.
|
| Context source |
Issaragrisil, S., et al. (1994). ‘Bone marrow transplantation in Thailand’. Transplantation Proceedings 26(4):2348-9. (RISCEN112)
|
| Subject field |
Haemopoiesis
|
| Generic concept |
Anemia
|
| Specific concept |
Acute aplastic anemia, chronic aplastic anemia, Blackfan-Diamond anemia, secondary aplastic anemias, Fanconi syndrome
|
| it |
Anemia aplastica
|
| Reliability code |
3
|
|
