Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| gene expression |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Definition |
The full use of the information in a gene via transcription and translation leading to production of a protein and hence the appearance of the phenotype determined by that gene. Gene expression is assumed to be controlled at various points in the sequence leading to protein synthesis and this control is thought to be the major determinant of cellular differentiation in eukaryotes.
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| Definition source |
Cancerweb. OMD – On-line Medical Dictionary.
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| Context |
Co-inheritance of an a-gene triplication, for instance, may increase a-gene expression and aggravate the b/a imbalance.
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| Context source |
Giordano, PC., et al. (1998). ‘Phenotype variability of the dominant beta-thalassemia induced in four Dutch families by the rare cd121 (G-->T) mutation’. Annals of Hematology 77(6):249-55. (RISCEN92)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Related concept |
Depletion, deletion, crossing-over, eradication, conditioning regimen, allogeneic bone marrow transplantation, gene transfection
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| it |
Espressione genica
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| Reliability code |
3
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