Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| unrelated donor |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
|
| Grammatical label |
Countable
|
| Variant |
Non-related donor
|
| Definition |
Transplantation from an unrelated donor carries a substantially increased risk, and should be considered only in exceptional circumstances. • The chance of success is highest when patients are well-chelated, with normal liver size and histology, and free of cardiac complications. Hepatic fibrosis and the presence of iron overload are important risk factors.
|
| Definition source |
Cao, A., et al. (1997). Management Protocol for the treatment of Thalassemia patients. Nicosia: Thalassemia International Federation. (LISCEN01)
|
| Context |
Among recipients of grafts from related donors other than HLA-matched siblings, more than half had donors mismatched at 2 or more loci; most of these transplants were T-cell depleted. In contrast, only one unrelated donor recipient pair was mismatched at 2 loci, and most unrelated donors were A, B, and DR (by serologic typing techniques for class I and molecular typing of DRB1) matched with their recipients. Most transplantations from unrelated donors were done in the 1990s.
|
| Context source |
Alexandra H., et al. (2001). ‘Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program’. Blood 97(6): 1598-1603. (RISCEN69)
|
| Antonym |
Related donor
|
| Subject field |
Haemopoiesis
|
| Sub-field (level 1) |
Thalassemias
|
| Sub-field (level 2) |
Therapies
|
| Generic concept |
HLA-compatible donor
|
| Related concept |
Allogeneic bone marrow transplantation, HLA typing, HLA, hematopoietic stem cell transplantation, Graft-Versus-Host Disease
|
| it |
Donatore non consanguineo
|
| Reliability code |
3
|
|
