Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| hba2 (en.) |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Variant |
A2 Hemoglobin
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| Definition |
The globin component consists of a tetrad of 574 amino acids in the form of 2 pairs of unlike polypeptide chains designated by Greek letters. Each molecule consists of 2 alpha and 2 nonalpha chains (eg, beta, gamma, delta) that have well-recognized and consistent amino acid sequences. In the normal adult hemoglobin (HbA), which constitutes over 95% of the hemoglobin in normal persons older than 1 year, the globin component consists of 2 alpha and 2 beta chains (alpha2beta2); the remaining hemoglobin comprises HbA2 (alpha2delta2) and fetal hemoglobin (HbF or alpha2gamma2).
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| Definition source |
Lawson, JP. (2001). Thalassemia. E-Medicine. (INTEEN09)
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| Context |
We postulated also in this family the presence of another molecular defect lying outside the b globin gene. This defect was present in the father of two of the patients who showed thalassemia-like red cell indices, normal HbF, low HbA2, and unbalanced a/non-a chain synthesis.
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| Context source |
Gasperini, D., et al. (1998). ‘Heterozygous beta-thalassemia with thalassemia intermedia phenotype’. American Journal of Hematology 57(1):43-7. (RISCEN170)
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| Subject field |
Haemopoiesis
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| Generic concept |
Globin chain, globin, hemoglobin
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| Coordinate concept |
Hb Gower 1, Hb Gower 2, Hb Portland, HbA, HbF
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| it |
HbA2 (It.)
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| Reliability code |
3
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