Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| hba (en.) |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Variant |
Adult Hb, adult hemoglobin
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| Definition |
The globin component consists of a tetrad of 574 amino acids in the form of 2 pairs of unlike polypeptide chains designated by Greek letters. Each molecule consists of 2 alpha and 2 nonalpha chains (eg, beta, gamma, delta) that have well-recognized and consistent amino acid sequences. In the normal adult hemoglobin (HbA), which constitutes over 95% of the hemoglobin in normal persons older than 1 year, the globin component consists of 2 alpha and 2 beta chains (alpha2beta2).
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| Definition source |
Lawson, JP. (2001). Thalassemia. E-Medicine. (INTEEN09)
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| Context |
By definition, the thalassemic defect may involve any of the chains; however, the syndromes commonly confronted by the clinicians concern the a and b-chains of the major Hb component of the human adult, i.e. HbA.
|
| Context source |
Loukopoulos, D. (1991). ‘Thalassemia: genotypes and phenotypes’. Annals of Hematology 62(4):85-94. Review. (RISCEN96)
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| Subject field |
Haemopoiesis
|
| Generic concept |
Globin chain, globin, hemoglobin
|
| Coordinate concept |
Hb Gower 1, Hb Gower 2, Hb Portland, HbA2, HbF
|
| Related concept |
Thalassemias
|
| it |
HbA (It.)
|
| Reliability code |
3
|
|
