Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| hbf (en.) |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
|
| Variant |
Fetal hemoglobin
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| Definition |
The globin component consists of a tetrad of 574 amino acids in the form of 2 pairs of unlike polypeptide chains designated by Greek letters. Each molecule consists of 2 alpha and 2 nonalpha chains (eg, beta, gamma, delta) that have well-recognized and consistent amino acid sequences. In the normal adult hemoglobin (HbA), which constitutes over 95% of the hemoglobin in normal persons older than 1 year, the globin component consists of 2 alpha and 2 beta chains (alpha2beta2); the remaining hemoglobin comprises HbA2 (alpha2delta2) and fetal hemoglobin (HbF or alpha2gamma2).
|
| Definition source |
Lawson, JP. (2001). Thalassemia. E-Medicine. (INTEEN09)
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| Context |
Of the four patients with a baseline HbF percent of less than 40, none responded to therapy. In contrast, four of the five patients with baseline HbF percent greater than 40 did respond.
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| Context source |
AA.VV. (1997). ‘Thalassemia Intermedia. A Region I Conference’. The Genetic Resource Special Issue, 1997, Volume 11, Number 2 (COSCEN01)
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| Subject field |
Haemopoiesis
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| Generic concept |
Globin chain, globin, hemoglobin
|
| Coordinate concept |
Hb Gower 1, Hb Gower 2, Hb Portland, HbA, HbA2
|
| it |
HbF (It.)
|
| Reliability code |
3
|
|
