| English |
| hereditary persistence of fetal hemoglobin |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
|
| Grammatical label |
Uncountable
|
| Variant |
HPFHb, Hereditary persistence of HbF
|
| Definition |
Hereditary persistence of foetal hemoglobin is a genetic condition where adult types of hemoglobin fail to develop and the types of hemoglobin the individual had as a foetus remains present well past the point when they would normally have stopped being produced.
|
| Definition source |
Cancerweb. OMD – On-line Medical Dictionary.
|
| Context |
The rationale for administration of various drugs to augment the production of fetal hemoglobin is based on the observation that in patients with hereditary persistence of fetal hemoglobin, the a/non-a chain synthesis ratio is balanced, resulting in longer red blood cell survival. Studies in animals suggested that such manipulations could be successful.
|
| Context source |
Rund, D. & Rachmilewitz, E. (2000). ‘New Trends in the treatment of beta-thalassemia’. Critical Reviews in Oncology/Hematology 33(2):105-18. (RISCEN189)
|
| Subject field |
Haemopoiesis
|
| Sub-field (level 1) |
Thalassemias
|
| Generic concept |
Disorders of the synthesis of d and b cahins
|
| Specific concept |
Heterozygous Hereditary Persistence of Fetal Hemoglobin, homozygous Hereditary Persistence of Fetal Hemoglobin
|
| Related concept |
Hemoglobin, catena globinica, globin, globin gene, Hb Bart´s, delta-beta-thalassemia, Hb Lepore
|
| it |
Persistenza Ereditaria di Emoglobina Fetale
|
| Reliability code |
3
|
