It was observed that the nature of the b-thalassemia mutations was not very different between the b-thalassemia major and b-thalassemia intermedia groups in our patients, but co-inheritance of one or more a-globin gene deletions was associated with lesser severity of the disease in Indians.
Nadkarni, A., et al. (2001). ‘Molecular pathogenesis and clinical variability of beta-thalassemia syndromes among Indians’. American Journal of Hematology 68(2):75-80. (RISCEN161)