Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| oral sicca |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Variant |
SS
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| Definition |
Oral Sicca (Also known as Sjörgen´s syndrome, SS) is a chronic, systemic inflammatory disorder of unknown cause, characterized by dryness of the mouth, and other mucous membranes and often associated with rheumatic disorders sharing certain autoimmune features (eg, RA, scleroderma, SLE) and in which lymphocytes infiltrate mucosal and other tissues. Sjögren´s syndrome (SS) is more common than SLE but less common than RA. An association has been found between HLA-DR3 antigens and primary SS in whites. Other genetic factors may be important in other ethnic group. SS may affect only the eyes or mouth (primary SS, sicca complex, sicca syndrome), or generalized collagen vascular disease (secondary SS) may be present. Arthritis occurs in about 33% of patients and is similar in distribution to that in RA; however, joint symptoms in primary SS tend to be milder and rarely lead to destruction. Some patients with undiagnosed SS who have rheumatic symptoms may not complain of sicca complex; SS is then diagnosed by laboratory evaluation. Salivary and lacrimal glands become infiltrated with CD4+ T cells and with some B cells. The T cells produce inflammatory cytokines. Salivary gland duct cells also produce cytokines, eventually damaging the secretory ducts. Atrophy of the secretory epithelium of the lacrimal glands causes desiccation of the cornea and conjunctiva. This most often produces a scratchy or irritated sensation. In advanced cases, the cornea is severely damaged, epithelial strands hang from the corneal surface (keratitis filiformis), and vision can be impaired.
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| Definition source |
The Merck Manual.
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| Context |
Patients with systemic lupus erythematosus have more sicca symptoms than do controls and they also have more oral sicca symptoms and less tear production than do patients with rheumatoid arthritis.
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| Context source |
Ghavamzadeh, A., et al. (1998). ‘Prognostic factors in bone marrow transplantation for beta thalassemia major: experiences from Iran’. Bone Marrow Transplantation 22(12):1267-1169. (RISCEN127)
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| Synonym |
Sjörgen´s syndrome
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Coordinate concept |
Hyperkeratosis, keratoconjunctivitis sicca, jaundice, hepatomegaly
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| Related concept |
Allogeneic bone marrow transplantation, hematopoietic stem cell transplantation
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| it |
Sindrome orale sicca
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| Reliability code |
3
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