Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| splicing (en.) |
  |
|
| Attestation |
3
|
| Part of speech |
Noun
|
| Grammatical label |
Countable
|
| Definition |
The process by which introns are removed from hnRNA to produce mature messenger RNA that contains only exons. Alternative splicing seems to occur in many proteins and by alternative exon usage a set of related proteins can be generated from one gene, often in a tissue or developmental stage specific manner.
|
| Definition source |
Cancerweb. OMD – On-line Medical Dictionary.
|
| Context |
On release, the hnRNA is processed into mature mRNA by splicing and addition of the poly-A tail, and is transported through the nuclear membrane into the cytoplasm by a complex mechanism. Once there, each mRNA molecule is attached to one, and subsequently more ribosomes, and is translated into globin chains by sequential addition of the appropriate amino acids to the C-terminal end of the methylated methionine which initiatess chain synthesis.
|
| Context source |
Loukopoulos, D. (1991). ‘Thalassemia: genotypes and phenotypes’. Annals of Hematology 62(4):85-94. Review. (RISCEN96)
|
| Subject field |
Haemopoiesis
|
| Sub-field (level 1) |
Thalassemias
|
| Related concept |
Deletion, promoter, globin gene, globin chain, globin, locus
|
| it |
Splicing (It.)
|
| Reliability code |
3
|
|
