Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| promoter (en.) |
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| Attestation |
3
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| Part of speech |
Noun
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| Grammatical label |
Countable
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| Definition |
In molecular biology, a site on DNA to which the enzyme RNA polymerase can bind and initiate the transcription of DNA into RNA.
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| Definition source |
MedicineNet. Medterms Medical Dictionary.
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| Context |
The first group of mild b-thalassemia mutations to be considered, involve the promoter area of the b-globin gene. Mutations in the promoter sequence result in a decreased production of b-globin mRNA. Of the mutations occurring in the TATA box, definite evidence demonstrating a mild defect of b-chain production is available for the -29 A to G substitution in the black population, the -31 A to G in the Japanese population and the -28 A to G in the Chinese population.
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| Context source |
Cao, A., et al. (1994). ‘Genotype-phenoptype correlations in beta-thalassemias’. Blood Reviews 8(1):1-12. Review (RISCEN85)
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| Subject field |
Haemopoiesis
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| Comprehensive concept |
Globin gene
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| Related concept |
Gene expression, locus, deletion, globin gene, globin chain, globin
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| it |
Promoter (It.)
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| Reliability code |
3
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