Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| cytomegalovirus |
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| Attestation |
3
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| Part of speech |
Noun
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| Grammatical label |
Countable
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| Variant |
CMV
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| Definition |
Cytomegalovirus (CMV) is a member of Betaherpesviridae in the subfamily Herpesviridae. CMV infection is worldwide and usually asymptomatic. CMV may cause a mononucleosis syndrome in the nonimmunocompromised host but is best recognized for causing disease in the immunocompromised host. It may cause disease in almost every organ of the body, resulting in pneumonia, hepatitis, encephalitis, colitis, uveitis, retinitis, neuropathy, and CMV syndrome. As with other herpesviruses, CMV establishes a latent infection of the host. CMV may reactivate during a period of immunosuppression secondary to drugs or intercurrent infection (eg, HIV). Genetic differences exist among viruses, which result in multiple strains of CMV. Differences in genotypes may be associated with differences in virulence. Becoming infected with more than one strain of CMV is possible and has been observed in organ transplant patients. The clinical significance of dual infection is not known. Duel infection has also been suggested to occur in CMV seropositive pregnant women with subsequent intrauterine infection and symptomatic congenital CMV.
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| Definition source |
E-Medicine - Instant Access to the Minds of Medicine.
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| Context |
In transfusion-dependent thalassemia patients some of these situations, such as a variable degree of iron overload, concomitant hepatitis B or cytomegalovirus infection and pre-existing fibrous liver damage, have been reported to have a synergistic effect with chronic HCV infection in accelerating liver damage.
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| Context source |
Centis, F., et al. (1997). ‘Increased serum levels of circulating intercellular adhesion molecule 1 predict the risk of graft rejection after bone marrow transplantation for thalassemia’. Bone Marrow Transplantation 20(2):125-128. (RISCEN130)
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| Figure source |
http://www.neuroanatomy.hpg.ig.com.br/nhp4.htm
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Generic concept |
Herpesvirus
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| Related concept |
Allogeneic bone marrow transplantation, hematopoietic stem cell transplantation, follow-up
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| it |
Citomegalovirus
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| Reliability code |
3
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