| English |
| lentivirus (en.) |
  |
|
| Attestation |
3
|
| Part of speech |
Noun
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| Grammatical label |
Countable
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| Definition |
A genus of the family retroviridae consisting of non-oncogenic retroviruses that produce multi-organ diseases characterised by long incubation periods and persistent infection. Lentiviruses are unique in that they contain open reading frames (orfs) between the pol and env genes and in the 3´ env region. Five serogroups are recognised, reflecting the mammalian hosts with which they are associated. HIV-1 is the type species.
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| Definition source |
Cancerweb. OMD – On-line Medical Dictionary.
|
| Context |
New families of retroviral vectors are being developed which include the foamy (spumavirus) virus famil and also lentiviruses. The advantage of these vectors over traditional retroviral vectors is that they seem to have a reduced requirement for cell division in order to allow infection. The need for cell division has presented a serious problem in retroviral gene transfer into hematopoietic stem cells, since manipulations such as the exposure to multiple cytokines was required for retroviral entry. This exposure was not only costly, but also seemed to push the stem cells toward differentiation, and therefore, true stem cells were not transduced. Future experiments will demonstrate if the newer viral vectors provide an advantage in overcoming these fundamental problems.
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| Context source |
Rund, D. & Rachmilewitz, E. (2000). ‘New Trends in the treatment of beta-thalassemia’. Critical Reviews in Oncology/Hematology 33(2):105-18. (RISCEN189)
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| Figure source |
http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/00.061.0.06.009.htm
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Generic concept |
Lentiviridae, retroviridae, viral vector
|
| Specific concept |
HIV, Maedi-Visna
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| Coordinate concept |
Retrovirus, herpes simplex, adeno-associated virus
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| Related concept |
Gene therapy, gene transfection
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| it |
Lentivirus (It.)
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| Reliability code |
3
|
