Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| antilymphocyte globulin |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Uncountable
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| Variant |
ALG
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| Definition |
Antilymphocyte globulin (ALG) is a polyclonal antisera derived from immunization of lymphocytes, lymphoblasts, or thymocytes into rabbits, goats, or horses. This agent has been used prophylactically as induction therapy during the early posttransplantation period and for treatment of acute rejection. Most centers reduce concomitant immunosuppression (eg, stop cyclosporine and lower azathioprine dose) to decrease infectious complications. Antithymocyte gamma globulin (ATGAM) is the only FDA-approved polyclonal preparation. Two rabbit immunoglobulin preparations, raised by immunization with thymocytes or with a human lymphoblastoid line, are scheduled for phase III multicenter testing versus ATGAM or OKT3, respectively. Potential side effects include fever, chills, erythema, thrombocytopenia, local phlebitis, serum sickness, and anaphylaxis. The potential for development of host anti-ALG antibodies has not been a significant problem because of the use of less immunogenic preparations and probably because ALG suppresses the immune response to the foreign protein itself.
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| Definition source |
Transplantation as Treatment of End-Stage Renal Disease.
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| Context |
Use of immunosuppressants, especially antilymphocyte globulin, have improved the prognosis of those patients who cannot receive a BMT from an HLA-identical sibling.
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| Context source |
Barth, E., et al. (2000). ‘Allogeneic bone marrow transplantation in hematologic disorders of childhood: new trends and controversies’. Haematologica 85(11 Suppl):2-8. Review. (RISCEN28)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Related concept |
Immunosuppression, conditioning regimen, rejection, Graft-Versus-Host Disease, metotrexate, cyclophosphamide, cyclosporine
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| it |
Globulina antilinfocitaria
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| Reliability code |
3
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