| English |
| total body irradiation |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
|
| Grammatical label |
Countable
|
| Variant |
TBI
|
| Definition |
Radiotherapy often given in several doses prior to bone marrow transplantation with the aim of killing any residual leukaemia or thalassemic bone marrow in the patient. It is used in conjunction with high-dose anti-cancer drugs. The procedure and its side-effects will be discussed individually with the patient.
|
| Definition source |
Cancerweb. OMD – On-line Medical Dictionary.
|
| Context |
All but 2 patients received a conditioning regimen including irradiation: either total body irradiation (n = 39, 56%) or thoracoabdominal irradiation (n = 28, 41%). The 2 patients who were not irradiated received higher doses of cyclophosphamide. A combination of cyclophosphamide 40 to 45 mg/kg total dose, anti-T serotherapy (anti-thymocyte globulin or monoclonal antibody), and total body irradiation was the most frequently used conditioning regimen (39%). Total body irradiation (P <.001) and anti-thymocyte globulin (P < 02) were more often used during the conditioning of patients who received T-cell-depleted grafts.
|
| Context source |
Ph. Guardiola, R., et al. (2000). ‘Outcome of 69 allogeneic stem cell transplantations for Fanconi anemia using HLA-matched unrelated donors: a study on behalf of the European Group for Blood and Marrow Transplantation’. Blood 95(2): 422-429. (RISCEN71)
|
| Subject field |
Haemopoiesis
|
| Sub-field (level 1) |
Thalassemias
|
| Sub-field (level 2) |
Therapies
|
| Generic concept |
Radiotherapy
|
| Related concept |
Conditioning regimen, eradication, marrow cavity, bone marrow space
|
| it |
Irradiazione total body
|
| Reliability code |
3
|
