Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| chelation |
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| Attestation |
3
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| Part of speech |
Noun
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| Grammatical label |
Countable
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| Definition |
Patients who require multiple blood transfusions, such as patients with thalassemia major, accumulate iron at a rate of approximately 0.5 mg/kg/day. This has a damaging effect on the liver, endocrine organs and especially the heart, resulting in premature death from cardiac arrhythmia or failure. Thus, iron chelation is of utmost importance in these patients. Although the goal of chelation is the reduction of toxic tissue iron stores and thereby, the prevention of end organ disease due to iron overload, another potential beneficial mechanism may be the removal of iron from the RBC membrane.
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| Definition source |
Rund, D. & Rachmilewitz, E. (2000). ‘New Trends in the treatment of beta-thalassemia’. Critical Reviews in Oncology/Hematology 33(2):105-18. (RISCEN189)
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| Context |
The iron chelation is considered successful when the iron burden in the body is maintained under toxic level for heart, liver and endocrine glands and generally it occurs when chelation is given regularly and at an adequate dosage. Obviously, the availability of an efficacious compound for the chelation of iron given orally must represent an important advantage for patients who need a continuous iron chelation and show intolerance or eventually resistance to DFO.
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| Context source |
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Specific concept |
Desferrioxamine, deferiprone, HES-DFO
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| Related concept |
Iron-chelating agent, transfusional therapy
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| it |
Chelazione
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| Reliability code |
3
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