Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| viral vector |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Variant |
Vector virus, vector
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| Definition |
Viral DNA that has been modified to serve as a vector for recombinant DNA.
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| Definition source |
Cancerweb. OMD – On-line Medical Dictionary.
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| Context |
To produce a retroviral vector, the genes, which normally encode the viral proteins, are removed and replaced by passenger genes. Using a “packaging” cell line which produces the viral proteins, the retroviral vector viruses may be free of any replication-competent helper virus. The retrovirus vectors can then perform one round of cell infection, but because they lack the genes to make virus proteins, they cannot produce new virus particles.42 Genes related to a wide range of genetic diseases, including hypoxanthine phosphoribosyi transferase (HPRT), adenosine deaminase (ADA), p-globin, B-glucocerebrosidase, the LDL receptor, growth hormone, and
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| Context source |
Gaziev, D., et al. (2000). ‘Bone marrow transplantation from alternative donors for thalassemia:HLA-phenotypically identical relative and HLA-nonidentical sibling or parent transplant’. Bone Marrow Transplantation 25(8):815-821. (RISCEN122)
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| Figure source |
http://sv.epfl.ch/intralen/anglais/viral.html
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Generic concept |
Gene vector
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| Specific concept |
Retrovirus, lentivirus, adeno-associated virus, herpes simplex
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| Related concept |
Gene therapy, gene transfection
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| it |
Virus vettore
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| Reliability code |
3
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