Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| liver biopsy |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Variant |
Hepatic biopsy
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| Definition |
Direct measurement of hepatic iron concentration is the most quantitative, specific, and sensitive method for determining the body iron burden in patients with thalassemia major. Liver biopsy is the best direct means of assessing iron deposition, permitting chemical measurement of the nonheme (storage) iron concentration and histochemical examination of the pattern of iron accumulation in hepatocytes and Kupffer cells, as well as evaluation of the extent of inflammation, fibrosis, and cirrhosis.
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| Definition source |
AA.VV. (1997). ‘Thalassemia Intermedia. A Region I Conference’. The Genetic Resource Special Issue, 1997, Volume 11, Number 2 (COSCEN01)
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| Context |
All patients underwent liver biopsies for clinical indications and all laboratory tests were done within 3 days before or after the cardiac study. Tissue was obtained from the right lobe of the liver by the subcostal route under ultrasound guidance using a 16-gauge needle. No liver biopsy-related complication was recorded. In the 32 patients studied, liver iron overload was evaluated semi-quantitatively (mild, moderate, severe) by described histology methods.
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| Context source |
Mariotti, E., et al. (1998). ‘Evaluation of cardiac status in iron-loaded thalassaemia patients following bone marrow transplantation: improvement in cardiac function during reduction in body iron burden’. British Journal of Haematology 103(4):916-21. (RISCEN98)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Generic concept |
Biopsy
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| Related concept |
Hepatomegaly, conditioning regimen, iron-chelation therapy
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| it |
Biopsia epatica
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| Reliability code |
3
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