| English |
| beta-thalassemia minor |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
|
| Grammatical label |
Countable
|
| Variant |
Beta thalassemia minor, b-thalassemia minor, b thalassemia minor
|
| Definition |
In b-thalassemia minor (ie, b-thalassemia trait or heterozygous carrier-type), one of the b-globin genes is defective. The defect can be a complete absence of the b-globin protein (ie, b0-thalassemia) or a reduced synthesis of the b-globin protein (ie, b+-thalassemia). The genetic defect usually is a missense or nonsense mutation in the b-globin gene, although occasional defects due to gene deletions of the b-globin gene and surrounding regions also have been reported.
|
| Definition source |
Takeshita, K. (2002). Thalassemia, Beta. E-Medicine. (INTEEN10)
|
| Context |
The occurrence rate of b-thalassemia minor in the northern part of Jordan was estimated at 3%-4% with a total of thirteen different b-thalassemia alleles, but its occurrence rate as well as its molecular bases have not been investigated in the other regions of the country.
|
| Context source |
Sadiq, MF., et al. (2001). ‘Spectrum of beta-thalassemia in Jordan: identification of two novel mutations’. American Journal of Hematology 68(1):16-22. (RISCEN163)
|
| Figure source |
http://www.emedicine.com/
|
| Synonym |
Beta-thalassemia minima, b-thalassemia trait, heterozygous carrier-type
|
| Subject field |
Haemopoiesis
|
| Sub-field (level 1) |
Thalassemias
|
| Generic concept |
Beta-thalassemias, b +-thalassemia
|
| Coordinate concept |
Beta-thalassemia major, beta-thalassemia intermedia
|
| it |
Beta-talassemia minor
|
| Reliability code |
3
|
