Medicina: Oncoematologia pediatrica: Leucemia linfoblastica acuta
| English |
| b-cell precursor all |
  |
|
| Attestation |
3
|
| Definition |
B-cell precursor ALL represents over 80% of childhood ALL cases. The B-lymphocytes lineage ALL cells derive when an uncommitted stem cell flounders somewhere in the pathway to becoming a mature B type plasma cell. Depending on where in the pathway the uncontrolled growth begins, the ALL is termed B-cell precursor, early pre-B-cell, pre-B, mature B-cell, etc. The three major types of B-lineage cells found in childhood ALL are: early pre-B, no surface or cytoplasmic immunoglobulin; pre-B, presence of cytoplasmic immunoglobulin; B-cell, presence of surface immunoglobulin.
|
| Definition source |
http://www.acor.org/ped-onc/diseases/ALL.html
|
| Context |
The need to evaluate a large group of patients receiving uniform treatment and to compare the outcome of TEL/AML1 with a cohort of B-cell precursor ALL known to have a good outcome, prompted us to investigate TEL/AML1 expression in ALL patients enrolled and treated with a traditional BFM schedule in two contemporary closed studies, ALL-BFM 90 and ALL-AIEOP 91.
|
| Context source |
en22
|
| Synonym |
B-precursor ALL.
|
| Subject field |
Pediatric Oncohematology
|
| Specific concept |
AUL, pre-pre B-ALL, pre-B cell ALL, common-ALL, early T ALL.
|
| de |
B-Vorläuferzell-ALL
|
| it |
LAL non T non B
|
| Reliability code |
3
|
|
