Medicina: Oncoematologia pediatrica: Leucemia linfoblastica acuta
| English |
| b-lineage all |
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| Attestation |
3
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| Definition |
Between 80% and 85% of ALL cases are of the B-cell lineage. B-lineage ALL is defined by the expression of: CD19, DR, CD 10 (CALLA, common acute lymphoblastic leukemia antigen), other B cell associated antigens. This group represents 80-85% of childhood ALL. The major subtypes are: early pre-B (early precursor-B)- no surface or cytoplasmic immunoglobulins, Pre-B (precursor-B)- cytoplasmic immunoglobulins, B-cell - surface immunoglobulins.
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| Definition source |
http://cancereducation.uams.edu/Modules/Leukemias/ALL/ALLPathophysiology.html
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| Context |
In all, this study has identified 12 new recurring cytogenetic aberrations in T-ALL. This series confirms that the karyotypic characteristics of childhood T-ALL are clearly different from those of B-lineage childhood ALL, supporting the notion that B-lineage ALL and T-ALL are biologically distinct neoplasms. Not only are the types and frequencies of chromosomal abnormalities very different in B-lineage ALL and T-ALL, but the contrast between the prognostic importance of blast karyotype in childhood B-lineage ALL versus its relative lack of importance in T-ALL is striking. Hyperdiploidy of 51-60 chromosomes, present in the leukemic blasts of about 25% of B-lineage pediatric ALL patients and associated with a good to excellent prognosis, is very uncommon in T-ALL and, when present, is not associated with any survival advantage. The recurring translocations of B-lineage ALL are very rarely seen in childhood T-ALL, whereas the 2 most common translocations in T-ALL, t(11;14) and t(10;14), are virtually never seen in B-lineage ALL. Most recurring translocations in B-lineage ALL are or have been associated with a poor prognosis, whereas t(10;14) in T-ALL may be associated with a higher rate of survival.
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| Context source |
en05
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| Figure source |
http://cancereducation.uams.edu/Modules/Leukemias/ALL/ALLPathophysiology.html
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| Synonym |
B-cell lineage ALL
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| Subject field |
Pediatric Oncohematology
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| Generic concept |
ALL
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| Specific concept |
B-cell ALL, B-cell precursor ALL
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| de |
B-Zellreihe
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| it |
LAL a fenotipo immunologico B
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| Reliability code |
3
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