Medicina: Oncoematologia pediatrica: Leucemia linfoblastica acuta
| English |
| prednisone response |
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| Attestation |
3
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| Definition |
Early blast cell reduction in peripheral blood. Prednisone response has emerged as the strongest predictor of outcome in childhood ALL. initial response to prednisone treatment is regarded as an important prognostic factor in infant ALL and it is used to stratify patients into prognostic categories for treatment assignment. Peripheral blood response to steroid prephase: Patients with a reduction in peripheral blast count to less than 1000/mm3 after a 7-day induction prephase with prednisone and one dose of intrathecal methotrexate (“good prednisone response”) have a more favorable prognosis than patients whose peripheral blast counts remain above 1000/1000/mm3 (“poor prednisone response ”).
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| Definition source |
en09
The prednisone response was defined as the cytoreduction (number of blood blasts per microliter at day 8) to a 7-day prednisone prephase and 1 intrathecal dose of methotrexate on day 1. Prednisone good responder (PGR; <1,000 blasts/µL) received conventional therapy and prednisone poor responder (PPR >1,000 blasts/µL) received intensified therapy.
en01
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| Context |
To verify whether the prednisone response could be used as a reliable stratification factor in infant ALL, we retrospectively analyzed the outcome of 106 infants with ALL according to presenting features and initial response to prednisone treatment; our results showed that the prednisone response was the strongest prognostic factor in infant ALL and might be used as a stratification factor in risk-adapted treatment protocols for infant ALL.
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| Context source |
en09
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| Subject field |
Pediatric Oncohematology
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| Specific concept |
PPR, PGR
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| Related concept |
clearance of leukemic cells, PPR, PGR, PCR, MRD
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| de |
Prednison-Response
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| it |
risposta al prednisone
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| Reliability code |
3
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