| English |
| mixed chimerism |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
|
| Grammatical label |
Countable
|
| Variant |
Complete chimerism, incomplete chimerism
|
| Definition |
Persistence of residual host hematopoietic cells has been observed after marrow transplantation and is commonly referred to as mixed chimerism (MC). There is evidence that, in some settings, MC in the marrow is associated with an increased risk of subsequent graft failure and/or disease recurrence. With the development of extremely sensitive techniques for detecting cells on the basis of their genetic origin, interpretation of this association has become more complicated, in part because of difficulties in identifying which cell lines are chimeric.
|
| Definition source |
Andreani, M., et al. (1996). ‘Persistence of mixed chimerism in patients transplanted for the treatment of thalassemia’. Blood 87(8):3494-9.
|
| Context |
It is expected that chimerism raised after allotransplantation will create a state of decreased responsiveness to donor antigens and slow down rejection of the transplanted tissues or organ. The question arises as to how the presence of microchimerism can be objectively documented and whether the live donor (tm)passenger cells or donor DNA are important in prolongation of allograft survival time.
|
| Context source |
Olszewski, WL., et al. (2000). ‘Donor DNA can be detected in recipient tissues during rejection of allograft’. Transplant International 13 Suppl 1:S461-4.
|
| Subject field |
Haemopoiesis
|
| Sub-field (level 1) |
Thalassemias
|
| Sub-field (level 2) |
Therapies
|
| Generic concept |
Chimerism
|
| Related concept |
Engraftment, Graft-Versus-Host Disease, rejection
|
| it |
Chimerismo misto
|
| Reliability code |
3
|
