Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| hemosiderosis |
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| Attestation |
3
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| Part of speech |
Noun
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| Grammatical label |
Uncountable
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| Variant |
Siderosis
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| Definition |
As a consequence transfusion, deposition of iron in the form of hemosiderin (an iron-protein complex) may occur in the myocardium, liver, and pancreas, as well as less commonly in the adrenals, thyroid, parathyroid, pituitary, and proximal small bowel. This may result in hemochromatosis and subsequent failure of these organs. CT may confirm the clinical diagnosis of hemochromatosis by demonstrating iron deposition, particularly in the liver; however, correlations with transfusion history, serum ferritin levels, and organ damage are unsatisfactory. MRI demonstrates deposits of hemosiderin, which is paramagnetic, in tissues and organs; however, MRI also fails to provide accurate monitoring of iron deposition in these thalassemic patients.
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| Definition source |
Lawson, JP. (2001). Thalassemia. E-Medicine. (INTEEN09)
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| Context |
In more than half of the patients who were under treatment at the time of the first survey (transfusion therapy with or without accompanying chelation therapy) hemosiderosis-related complications were reported.
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| Context source |
Cario, H., et al. (2000). ‘Epidemiological situation and treatment of patients with thalassemia major in Germany: results of the German multicenter beta-thalassemia study’. Annals of Hematology 79(1):7-12. (RISCEN88)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Specific concept |
Cardiac hemosiderosis, liver hemosiderosis, pumonary hemosiderosis, liver siderosis
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| Coordinate concept |
Hemochromatosis
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| Related concept |
Hepatosplenomegaly, iron-chelation therapy, iron-chelating agent, hemoglobin, myocardiopathy
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| it |
Emosiderosi
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| Reliability code |
3
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