Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| extramedullary hematopoiesis |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Variant |
Extramedullary haemopoiesis
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| Definition |
In the most severely affected patients, and in particular, in patients with thalassemia intermedia, prominent lobulated soft-tissue densities may be noted in the posterior mediastinum and, to a lesser degree, in the anterior mediastinum or pelvis. These opacities result from extramedullary hematopoiesis. CT, which can evaluate the skeletal system in the axial plane, demonstrates that this proliferating marrow originates within the medulla of adjacent vertebral bodies, ribs, or pelvis. Although extramedullary, it remains subperiosteal in location and, histologically, shows new bone formation. The presence of extramedullary hematopoiesis within the spinal canal may be associated with the development of spinal cord compression.
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| Definition source |
Lawson, JP. (2001). Thalassemia. E-Medicine. (INTEEN09)
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| Context |
Anemia and ineffective erythropoiesis are strong formuli for enhanced compensatory erythropoiesis that results in bone marrow expansion and in extramedullary hematopoiesis.
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| Context source |
Divoky, V., et al. (2001). ‘Non-anemic homozygous beta(o) thalassemia in an African-American family: association of high fetal hemoglobin levels with beta thalassemia alleles’. American Journal of Hematology 68(1):43-50. (RISCEN162)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Generic concept |
Haemopoiesis
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| Related concept |
Hepatosplenomegaly, hepatopathy, transfusional therapy
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| it |
Ematopoiesi extramidollare
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| Reliability code |
3
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