Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| double heterozygosity |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Definition |
Presence of two heterozigote defects, for example for the HbS and b-thalassaemia genes. In this case there the result is a severe haemolytic anaemia with prominent splenomegaly, with sickling crises. The condition is common in Mediterranean subjects. Hemoglobin E/a-thalassemia in another an important double heterozygous condition which results in a severe transfusion-dependent thalassemia or thalassaemia intermedia phenotype. The clinical picture may be indistinguishable from that of b-thalassaemia major. It is found in Southeast Asia and India.
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| Definition source |
MedicineNet. Medterms Medical Dictionary.
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| Context |
Moreover, in two previous reports, heterozygous carriers of both b-thalassemia trait and SEA deletion in the Chinese who were described all showed MCV values of below 80 fL, further supporting that this cut-off limit is applicable to the detection of double heterozygosity for b -thalassemia trait and SEA deletion.
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| Context source |
Ma, ES., et al. (2001). ‘Thalassemia screening based on red cell indices in the Chinese’. Haematologica 86(12):1310-1. (RISCEN20)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Related concept |
Alpha-thalassemias
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| it |
Doppia eterozigosi
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| Reliability code |
3
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