Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| myocardiopathy |
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| Attestation |
3
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| Part of speech |
Noun
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| Grammatical label |
Countable
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| Definition |
The high prevalence of cardiac and endocrine disorders cush as miocardiopathy in the older thalassemic patients, as well as the increasing number of patients affected by cardiac disease, is alarming and requires special attention. As a result, the particular problems of preventing and treating siderotic complications in these patients require more and more attention. The difficulty of insufficient compliance with chelation therapy, discussed repeatedly, seems to be particularly important for adolescents. An important factor might be the increasing need for self-responsibility, which is not met by the patients, in connection with particular aspects of psychological development during this period of life. Transfusional iron overload leading to miocardiopathy and other severe complications continues to be a major problem in chronically transfused homozygous b-thalassaemia patients. It is well known that young red cells (neocytes) survive longer after transfusion and therefore may contribute to the extension of the intervals between transfusions.
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| Definition source |
Spanos, T., et al. (1996). ‘The impact of neocyte transfusion in the management of thalassaemia’. Vox Sanguinis 70(4):217-23.
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| Context |
The long-term effects of BMT in thalassemia are being monitored in patients transplanted between 1987-1995 and compared with those subjects matched for age and treated during the same period with conventional therapy. The incidences of fulminant sepsis and growth impairment are significantly higher in transplanted patients, whereas the-occurrence of hypothyroidism, hypogonadism, and myocardiopathy are higher in the other group of patients. Non-significant differences are observed in the incidences of diabetes, liver disease, and severe infections.
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| Context source |
Barth, E., et al. (2000). ‘Allogeneic bone marrow transplantation in hematologic disorders of childhood: new trends and controversies’. Haematologica 85(11 Suppl):2-8. Review. (RISCEN28)
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| Subject field |
Haemopoiesis
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| Specific concept |
Myocardiosclerosis
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| Related concept |
Hemosiderosis, iron-chelation therapy, iron overload
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| it |
Miocardiopatia
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| Reliability code |
3
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