Medicina: Oncoematologia pediatrica: Leucemia linfoblastica acuta
| English |
| aml |
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| Attestation |
3
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| Variant |
Acute Myelogenous Leukemia, Acute Myeloid Leukemia, Acute Myelocytic Leukemia.
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| Definition |
A progressive cancer that starts by the malignant transformation of an immature cell in the bone marrow. This affected cell usually is a primitive multipotential cell, meaning that its normal counterpart can give rise to a variety of blood cells. The transformed cell multiplies and accumulates in the marrow as leukemic myeloblasts. AML can occur at any age but increases exponentially in incidence after age 45 years. This leukemia can have a myriad of genetic alterations and the appearance of the leukemic cells can be represented by many different subtypes. Although several genetic changes, especially translocations of chromosomes, are relatively common, a large proportion of patients has uncommon or rare genetic changes.
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| Definition source |
http://www.leukemia.org/all_glossary.adp
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| Context |
In childhood AML, chemotherapy results have always been inferior to those in ALL. Thus in AML, allogeneic bone marrow was proposed as a primary form of therapy.
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| Context source |
en02
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| Synonym |
ANLL, acute non-lymphocytic leukemia.
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| Subject field |
Pediatric Oncohematology
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| Generic concept |
acute leukemia
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| de |
AML
|
| it |
LMA
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| Reliability code |
3
|
|
