Medicina: Oncoematologia pediatrica: Leucemia linfoblastica acuta
| English |
| cyclophosphamide |
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| Attestation |
3
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| Definition |
an immunosuppressive and antineoplastic drug C7H15Cl2N2O2P used in the treatment of lymphomas and some leukemias
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| Definition source |
Merriam-Webster´s Medical Dictionary
http://www.lymphomainfo.net/therapy/drugs/cytoxan.html
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| Context |
Continuation therapy for higher-risk cases consisted of drug pairs administered in weekly rotation: etoposide plus cyclophosphamide, mercaptopurine plus methotrexate, methotrexate plus cytarabine, prednisone plus vincristine plus asparaginase, etoposide plus cyclophosphamide, mercaptopurine plus high-dose methotrexate (replaced by low-dose methotrexate after 1 year of therapy), etoposide plus cytarabine, and prednisone plus vincristine plus asparaginase.
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| Context source |
en29
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| Synonym |
CPM
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| Subject field |
Pediatric Oncohematology
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| Generic concept |
alkylating agents
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| Coordinate concept |
Cyclophosphamide (brand names Cytoxan, Neosar in the US, cytoxan or procytox in Canada) is a chemotherapy agent used in the treatment of Non-Hodgkin´s lymphoma (NHL) and other forms of cancer. For NHL it is more often than not given in conjunction with other chemotherapy agents in a multidrug regimen. This drug is an alkalyzing agent, disrupting cancer growth. Short Term Side Effects: Common: nausea and vomiting (ask your doctor about drugs to counteract nausea), diarrhea, menstrual irregularity, alopecia (hair loss), fatigue, darkening of nails or skin; Long Term Side Effects: hair loss (alopecia) during use - hair growth should return after treatment. This drug has been known to affect fertility.
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| de |
CPM
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| it |
CPM
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| Reliability code |
3
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