Increased pressure of the cerebrospinal fluid. If symmetrically distributed it may have few neurologic symptoms (e.g., pseudotumor cerebri), but if it is asymmetrical (as in hydrocephalus), neurological symptoms are often severe.
Intracranial hypertension has been reported in a small number of children treated with growth hormone. Patients should be monitored closely for evidence of this disorder: papilledema, visual changes, headache, nausea, and/or vomiting .