Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| bone marrow hyperactivity |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Variant |
Hyperactivity of the bone marrow, marrow hyperactivity
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| Definition |
Hyperactivity of the erythropoietic tissue in the bone marrow, a typical condition in thalassemia major and, to a lesser degree, also in simple thalassemic heterozygosis. In fact, in healthy carriers there is hyperplasia of the bone marrow which only affects the erythroid series, and which is characterized by a high prevalence of normo-erythroblasts.
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| Definition source |
Bianco Silvestroni, I., et al. (2000). ‘Serum levels of erythropoietin and soluble transferrin receptor in the course of pregnancy in non beta thalassemic and beta thalassemic women’. Haematologica 85(9):902-7. (RISCEN34)
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| Context |
The pre-transfusion Hb should be high enough to inhibit marrow hyperactivity. In general, an Hb level of 9.5 - 10 g/dL is sufficient, though the exact level can vary with the Thalassaemia mutations involved, the patient´s age, and presence or absence of the spleen.
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| Context source |
Cao, A., et al. (1997). Management Protocol for the treatment of Thalassemia patients. Nicosia: Thalassemia International Federation. (LISCEN01)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| it |
Iperattività midollare
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| Reliability code |
3
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