Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| delta-beta-thalassemia |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Countable
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| Variant |
db-thalassemia, db thalassemia, db-thal, delta-beta thalassemia, deltabeta-thalassemia, deltabeta thalassemia, delta-beta-thal
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| Definition |
This group of conditions is characterized by deletions involving at least part of the delta- and beta-globin genes. Often the deletion is much larger and includes the entire delta and beta genes, and sometimes the Agamma or the Agamma, Ggamma, and epsilon genes. The phenotype of the heterozygote is comparable to that of a beta°-thal. Four different groups are recognized: V-a. The GgammaAgamma(deltabeta)°-thal alleles; V-b. The Lepore Hbs; V-c. The Ggamma(Agammadeltabeta)°-thal alleles; V-d. The (epsilongammadeltabeta)°-thal alleles.
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| Definition source |
Huisman, T.H.J., et al. (1997). A Syllabus of Thalassemia mutations. Augusta (USA): The Sickle Cell Anemia Foundation.
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| Context |
Twelve known b-thalassaemia mutations were identified in 72 out of the 73 patients, as listed in Table 1. The remaining patient was found to be homozygous for db -thalassaemia (Sicilian type).
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| Context source |
Qatanani, M., et al. (2000). ‘Beta-thalassaemia intermedia in Lebanon’. European Journal of Haematology 64(4):237-44. (RISCEN139)
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| Synonym |
F-thalassemia
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Generic concept |
Thalassemias, microcythemia
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| Specific concept |
Delta-beta-thalassemia intermedia, delta-beta-thalassemia minor
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| it |
Delta-beta-talassemia
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| Reliability code |
3
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