| English |
| transferrin saturation |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
|
| Grammatical label |
Countable
|
| Definition |
Chelation is initiated when the transferrin approaches complete saturation; generally this is when the ferritin reaches 1000 ng/ml. As described elsewhere, this is preceded by a detailed educational program that includes Child Life, Social Services, Psychological and Home Care Services. Young children are started at reduced doses. Desferal is infused a minimum of 8-12 hours/day subcutaneously for a minimum of 5 days/week.
|
| Definition source |
Children’s Hospital Oakland. Medical Section. (INDIEN01)
|
| Context |
We treated 18 heavily iron-loaded patients who had become ex-thalassaemics after bone marrow transplantation with subcutaneous desferrioxamine therapy for 5-20 months. As determined using serum ferritin concentration, transferrin saturation and stainable liver iron obtained in follow-up biopsies, marked decreases in body iron stores were observed with this regimen. Moreover, the liver function tests demonstrate a trend to normalization in all cases.
|
| Context source |
Giardini, C., et al. (1995). ‘Desferrioxamine therapy accelerates clearance of iron deposits after bone marrow transplantation for thalassaemia’. British Journal of Haematology 89(4):868-73. (RISCEN101)
|
| Subject field |
Haemopoiesis
|
| Sub-field (level 1) |
Thalassemias
|
| Related concept |
Iron-chelation therapy, iron-chelating agent, iron overload
|
| it |
Saturazione transferrinica
|
| Reliability code |
3
|
