Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| microcythemia |
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| Attestation |
3
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| Part of speech |
Noun
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| Grammatical label |
Countable
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| Definition |
Microcythemias are a diverse group of inherited disorders in which the rate of production of certain hemoglobins is decreased leading to an imbalance of globin chains available for hemoglobin dimer construction. This results in the formation of abnormal amounts of structurally normal (normal amino acid sequence) hemoglobins. For instance, if inadequate numbers of b-chains were synthesized, a-chains would be in relative excess. The excess a-chains combine with other available globin chains to form increased amounts of HbA2 and HbFor Hb Bart´s.
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| Definition source |
University of Virginia. Red Cell Disorders – Thalassemia
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| Context |
The first figures on the diffusion of microcythemia in Italy have revealed that insular areas of Southern Italy have the highest incidence of microcythemia. Furthermore, within these areas, the incidence was highest in coastal areas. However, massive shifts of the population from the South to the industrial areas of the North in the fifties gave rise to new hotbeds of microcythemia in outlying areas of Genoa, Milan and Turin.
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| Context source |
Vania, A., et al. (1998). ‘Thalassemic syndromes in Latium: epidemiological evaluation’. Haematologica 83(6):525-32. (RISCEN47)
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| Synonym |
Thalassemias, talassemic syndromes, thalassemic diseases, microcythemic syndromes
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| it |
Microcitemia
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| Reliability code |
3
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