| English |
| skull with hair-on-end appearance |
  |
|
| Attestation |
3
|
| Part of speech |
Noun syntagm
|
| Grammatical label |
Countable
|
| Variant |
“Hair-on-end” appearance
|
| Definition |
In severely affected patients, a widening of the diploic space (medulla) with a thinning of the tables (cortices) occurs, frequently with complete obliteration of the outer table. New bone forms in response to marrow proliferation beneath the periosteum. These bony spicules may be seen radiographically and result in a classic “hair-on-end” appearance. Because it lacks hematopoietic marrow, the occipital bone usually is not involved. Proliferation of marrow within the frontal and facial bones impedes pneumatization of the paranasal sinuses. This results in hypertrophy of osseous structures and a consequent prominence of the lateral margins of the malar eminences, together with anterior and medial displacement of developing teeth. These features explain the clinical findings noted by Cooley.
|
| Definition source |
Lawson, JP. (2001). Thalassemia. E-Medicine. (INTEEN09)
|
| Context |
The skeletal abnormalities observed in patients with thalassemia major include an expanded bone marrow space, resulting in the thinning of the bone cortex. These changes are particularly dramatic in the skull, which may show the characteristic hair-on-end appearance. Bone changes also can be observed in the long bones, vertebrae, and pelvis.
|
| Context source |
Takeshita, K. (2002). Thalassemia, Beta. E-Medicine. (INTEEN10)
|
| Figure source |
http://genetic_letters.tripod.com/
|
| Synonym |
Thalassemic facies, facies resembling the Mongolian race
|
| Subject field |
Haemopoiesis
|
| Sub-field (level 1) |
Thalassemias
|
| Generic concept |
Radiologic alteration, somatic alteration
|
| it |
Cranio a spazzola
|
| Reliability code |
3
|
