Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| diabetes mellitus |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Uncountable
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| Definition |
Diabetes mellitus (DM) is a chronic metabolic disorder caused by an absolute or relative deficiency of insulin, an anabolic hormone. Insulin is produced in the pancreas by the beta cells of the islets of Langerhans. Absence, destruction, or loss of these cells causes an absolute deficiency of insulin, leading to type 1 diabetes (insulin-dependent diabetes mellitus [IDDM]). Most children with diabetes have IDDM and a lifetime dependence on exogenous insulin.Type 2 diabetes (non–insulin-dependent diabetes mellitus [NIDDM]) is a heterogeneous disorder. Patients with NIDDM have insulin resistance, and their beta cells lack the ability to overcome this resistance. Although this form of diabetes previously was uncommon in children, 20% or more of new patients with diabetes in childhood and adolescence now have NIDDM, a change associated with increased rates of obesity.
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| Definition source |
E-Medicine - Instant Access to the Minds of Medicine.
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| Context |
However, due to lack of an effective means for excreting excess iron, blood transfusion results in an inexorable accumulation of tissue iron that may cause hepatic and endocrine abnormalities, growth retardation, diabetes mellitus and cardiac failure.
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| Context source |
Taher, A., et al. (2001). ‘Comparison between deferoxamine and deferiprone (L1) in iron-loaded thalassemia patients’. European Journal of Haematology 67(1):30-4. (RISCEN135)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Generic concept |
Diabetes
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| Specific concept |
Non-insulin dependent diabetes mellitus, insulin dependent diabetes mellitus
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| it |
Diabete mellito
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| Reliability code |
3
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