Medicina: Ematologia: Talassemie e trapianto del midollo osseo
| English |
| hemolysis |
  |
|
| Attestation |
3
|
| Part of speech |
Noun
|
| Grammatical label |
Uncountable
|
| Variant |
Hyperhemolysis
|
| Definition |
The destruction of red blood cells which leads to the release of hemoglobin from within the red blood cells into the blood plasma. In b-thalassemia, the excess unpaired alpha-globin chains aggregate to form precipitates that damage red cell membranes, resulting in intravascular hemolysis. Premature destruction of erythroid precursors results in intramedullary death and ineffective erythropoiesis.
|
| Definition source |
Takeshita, K. (2002). Thalassemia, Beta. E-Medicine.
|
| Context |
Iron kinetics studies may be useful because thalassemia intermedia patients have a higher radioactive iron medullary uptake, less ineffective erythropoiesis and greater peripheral hemolysis compared to patients who develop thalassemia major.
|
| Context source |
Cao, A., et al. (1994). ‘Genotype-phenoptype correlations in beta-thalassemias’. Blood Reviews 8(1):1-12. Review (RISCEN85)
|
| Subject field |
Haemopoiesis
|
| Specific concept |
Acute hemolysis, chronic hemolysis, immunomediated hemolysis, periferic hemolysis
|
| it |
Emolisi
|
| Reliability code |
3
|
|
